Galleria mellonella in vitro model for chromoblastomycosis shows large differences in virulence between isolates

IMA Fungus

Table 1 General information of the nine strains of Cladophialophora spp. tested in this study

Species	Isolate Nr	Source	Origin	Growth Temp. (°C )			MIC (mg/L)
Species	Isolate Nr	Source	Origin	Range/optimum	37 °C	AmB	ITR	VOR	POS	TER
C. carrionii	CBS 131838	Human CBM	China, Shandong	12–37/30	+	4	0.016	0.063	0.016	0.016
C. carrionii	CBS 114402	Human CBM	Venezuela, Falcón	9–37/30	+	2	0.125	0.25	0.031	0.063
C. carrionii	CBS 100434	Human	Madagascar	12–37/30	+	0.5	0.031	0.25	0.031	0.031
C. carrionii	CBS 117900	Human CBM	Venezuela, Falcón	15–37/27–30	+	1	0.063	1	0.063	0.125
C. carrionii	CBS 861.96	Dry plant debris	Venezuela, Falcón	9–37/27	+	8	0.031	0.5	0.031	0.063
C. carrionii	CBS 131736	Soil	Venezuela	9–37/30	+	4	0.031	0.125	0.063	0.25
C. yegresii	CBS 114405	Cactus	Venezuela, Falcón State	12–33/27	–	0.25	0.25	0.063	0.125	0.063
C. yegresii	CBS 114406	Cactus	Venezuela, Falcón State	12–33/27	–	0.25	0.5	0.125	0.125	0.063
C. yegresii	CBS 114407	Cactus	Venezuela, Falcón State	12–33/27	–	0.5	0. 25	0.125	0.125	0.063

C. carrionii: Cladophialophora carrionii; C. yegresii: Cladophialophora yegresii; Growth Temp: growth tempreture on Sabouraud’s Glucose Agar. MIC: Minimum inhibitory concentration; AMB: Amphotericin B; ITR: Itraconazole; VOR:Voriconazole; POS: Posaconazole; TER: Terbinafine

ISSN: 2210-6359