Table 3 Diagnostic accuracy of different low CrAg LFA titers in patients with different immune status
Threshold | Value % (95% CI) | |||
|---|---|---|---|---|
Sensitivity | Specificitya | PPV | NPV | |
Serum | ||||
= 1:10 | 39.6 (29.7–50.1) | 100.0 (69.2–100.0) | 100.0 (90.7–100.0) | 14.7 (7.3–25.4) |
With predisposing factors | 33.3 (16.5–54.0) | 100.0 (54.1–100.0) | 100.0 (66.4–100.0) | 25.0 (9.8–46.7) |
Without predisposing factors | 42.0 (30.2–54.5) | 100.0 (39.8–100.0) | 100.0 (88.1–100.0) | 9.1 (2.5–21.7) |
≥ 1:5 | 72.9 (62.9–81.5) | 70.0 (34.8–93.3) | 95.9 (88.5–99.1) | 21.2 (9.0–38.9) |
With predisposing factors | 70.4 (49.8–86.2) | 66.7 (22.2–95.7) | 90.5 (69.6–98.8) | 33.3 (9.9–65.1) |
Without predisposing factors | 73.9 (61.9–83.7) | 75.0 (19.4–99.4) | 98.1 (89.7–100.0) | 14.3 (3.0–36.3) |
CSF | ||||
= 1:10 | 50.0 (21.1–78.9) | / | 100.0 (54.1–100.0) | 0.0 (0.0–45.9) |
With predisposing factors | 33.3 (4.3–77.7) | / | 100.0 (15.8–100.0) | 0.0 (0.0–60.2) |
Without predisposing factors | 66.7 (22.3–95.7) | / | 100.0 (39.8–100.0) | 0.0 (0.0–84.2) |
≥ 1:5 | 66.7 (34.9–90.1) | / | 100.0 (63.1–100.0) | 0.0 (0.0–60.2) |
With predisposing factors | 50.0 (11.8–88.2) | / | 100.0 (29.2–100.0) | 0.0 (0.0–70.8) |
Without predisposing factors | 83.3 (35.9–99.6) | / | 100.0 (47.8–100.0) | 0.0 (0.0–97.5) |