Table 3 Biological activity of melinacidin IV and chetracin B against the drug resistant Gram-positive bacteria, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) and the Gram-negative bacterium Proteus vulgaris along with antibiotics tested as a positive control. All assays were run in triplicate, averaged and activity values are expressed in μM. If an assay was not performed, table entry was left blank. MIC: minimal inhibitory concentration. IC50: half maximal inhibitory concentration.
MRSA | VRE | P. vulgaris | ||||
|---|---|---|---|---|---|---|
Compound | MIC | IC 50 | MIC | IC 50 | MIC | IC 50 |
melinacidin IV | 0.7 | 0.1 | 22 | 6 | 175.8 | 71.4 |
chetracin B | 0.7 | 0.2 | 10.5 | 1.1 | 168.4 | 76.3 |
vancomycin | 1.4 | 0.6 | - | - | - | - |
rifampicin | - | - | 2.4 | 1 | - | - |
ciprofloxacin | - | - | - | - | 0.024 | 0.012 |