Overview of MSDIN family genes in the three amanitin-producing agaric genera. Upper left indicates the best represented consensus sequence, with a general schematic structure of MSDIN genes with leader peptide, core peptide, and recognition sequence (not including the core peptide, the hypervariable region). Coloured boxes harbor species from specific geological locations. Coloured (red and green) letters indicate variations (differences) compared with the consensus sequence. In G. marginata and L. brunneoincarnata, green letters also designate conserved amino acids only between the two species. MSDIN sequences are underlined, and true MSDIN sequences are only found in Amanita species.