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Table 2 MSDIN peptide sequences from Amanita subjunquillea (As).

From: The MSDIN family in amanitin-producing mushrooms and evolution of the prolyl oligopeptidase genes

No.

Leader peptide

Core Peptide

Recognition Sequence

Scaffold

Coding and Notes

1

MSDINATCLP

IWGIGCNP

IWGIGCNP

1

α-amanitin

2

MSDINATRLP

IWGIGCNP

IWGIGCNP

1

β-amanitin

3

MSDINATRLP

IWGIGCDP

CIGDDVTALLTRGEALC

1

β-amanitin

4

MSDINATRLP

AWLVDCP

CVGDDVTALLTRGEALC

1

phallacidin

5

MSDINTARLP

HFASFIPP

CIGDDVTALLTRGEALC

1

 

6

MSDINTARLP

TFLPPLFVPP

CVSDDVTALLTRGEALC

1

 

7

MSDINATRLP

AWLATCP

CAGDDVTALLTRGEALC

2

phalloidin

8

MSDINATRLP

LNILPFMLPP

CVGDDVTALLTRGEALC

54

 

9

MSDMNATRLP

LIQRPFAP

CVSDDVTALLTRGEALC

41

 

10

MSDMNATRLP

LIQRPYAP

CVSDDVTALLTRGEALC

10

 

11

MFDINITRLP

IFWFIYFP

CVGDDVTALLTRGEALC

8

 

12

MSDINTARLP

IGRPESIP

CVGDDVTALLTRGEALC

13

 

13

MSDINTARLP

LRLPPFMIPP

CVGDDVTALLTRGEALC

13

 

14

MSDMNVARLP

ISDPTAYP

CVGGDVTALLTRGEALC

13

2 copies, in Apa

15

MSDINTVCLP

LQKPWSRP

CVGDDVTALLTRGEALC

13

 

16

MSDVNATRLP

FNFFRFPYP

CIGDDVTALLTRGEALC

38

 

17

MSDINATRLP

SSVLPRP

CVGDDVTALLTRGEALC

20

 

18

MSDMNVARLP

ISDPTAYP

CVGGDVTALLTRGEALC

22

2 copies, in Apa

  1. Core peptides (correspond to cyclic peptide toxins) are in bold.
  2. The conserved MSDIN (except for the ones with variations) is underlined.
  3. No. 14 and 18 have two copies and are also in A. pallidorosea.